Research Evidence Anecdotal Efficacy Side Effects Price Dosing & Protocol Peptide Deep Dive Regulatory Safety Notes

VIP

Human evidence for VIP is limited — pilot studies, withdrawn trials, or completed trials without posted results. Off-label / exploratory data exists for 10 additional indications (Pharmacokinetic / healthy volunteer studies; Covid19).

Research Evidence

Evidence shape

Depthhow much

11 registered trials

10 completed · 1 recruiting / active

Breadthhow many areas

11 indications mapped

10 thin / exploratory · 1 animal-only · 9 single-trial long-tail

Qualityhow rigorous

Highest tier: Phase 3

7 distinct sponsors · 4 linked publications on registered trials

Breadth and depth35 rows captured

Human

direct clinical signal

11

Animal

translational support

12

In vitro

mechanistic support

12

HighMediumLow

Anecdotal efficacy

Inflammation & Immune Modulation

3 linked reports sit in this bucket. The captured signal currently skews positive, with 100% positive, 0% mixed, and 0% negative.

1-3 of 3

+“It helped a lot with general inflammation”r/Peptides · 1 upvotes +“HS-CRP went down from 8.6 to 3.5”r/Peptides · 1 upvotes +“I think it's helped with systemic inflammation, brain fog and with my POTS symptoms”r/PeptideGuide · 5 upvotes

Side effects

Clinical research side effects

Clinical safety table not projected yet.

Anecdotal side effects

Side effect source data

28 linked sources are available across clinical rows and community reports.

Clinical 0Anecdotal 28

1-4 of 28

General / systemic

“I'd just hate for your blood pressure to drop to much like mine did as my body completely freaked out from that.”Other (uncategorised) · r/CIRS · 2 upvotes

General / systemic

“My PMS also gets bad.”Other (uncategorised) · r/CIRS · 2 upvotes

General / systemic

“First time I got GI symptoms that necessitated stopping.”Other (uncategorised) · r/CIRS · stopped over this · 1 upvotes

General / systemic

“I did the tolerance test (one squirt) and had a drop in blood pressure briefly and then my diastolic rose”Other (uncategorised) · r/CIRS · 1 upvotes

Price

1

Nextgenpeps

10 mg

$0.99

$0.099/mg

2

Puratek Peptides

10 mg

$31.45

$3.15/mg

3

Evolve BioPep

10 mg

$38.00

$3.8/mg

4

Peptide Titans

100 mg

$439.99

$4.4/mg

5

Nextgen Peptides

10 mg

$45.00

$4.5/mg

6

Nexaph

100 mg

$458.00

$4.58/mg

price offers can be sorted by column

1-6 of 59

Dosing & Protocol

How VIP is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.

Research trials

Published clinical-trial protocols · n = 10

Typical dose

No quantified dose captured for this tier.

Frequency: unspecified
Timing: unspecified
Route: unspecified
Cycle: unspecified

10 completed trials identified; trial dosing not reliably extracted from registry data.

8 sources

Clinician practice

Doctor & published-protocol guidance · n = 2

Typical dose

200 µg

200 µg
200 µg

Frequency: daily
Timing: unspecified
Route: subQ
Cycle: unspecified

Clinician protocols dose 200 µg daily subQ (2 sources).

2 sources

Anecdotal

Community-reported real-world use · n = 6

Typical dose

No quantified dose captured for this tier.

Frequency: unspecified
Timing: unspecified
Route: unspecified
Cycle: unspecified

Anecdotal reports involving VIP are positive regarding its use for inflammatory conditions (3 of 3 reports) and neuroprotection/headache relief (2 of 3 reports positive). However, specific dosing information from community posts is not available.

Dose & protocol sources

10 linked sources are available across the research, clinician, and community tiers. Each card states what that source says, with a link to it.

Research trials 8Clinician practice 2Anecdotal 0

Research trialsNCT04872231

Number of participants who experience Adverse Events (AEs), Serious Adverse Events (SAEs) and withdrawals due to AEs

NCT04872231 · Phase 1 ↗

Research trialsNCT00255320

Headache intensity, Mean velocity of blood flow in the middle cerebral artery (VmeanMCA), superfical temporal artery diameter, PetCO2, adverse events and vital signs were recorded at T-10, T0 and then every 10 min until 120 min after start of infusion.

NCT00255320 ↗

Research trialsNCT04844580

Clinical improvement

NCT04844580 · Phase 2 ↗

Research trialsNCT04260035

Occurrence of migraine-like attacks

NCT04260035 ↗

Research trialsNCT03989817

Change in cranial hemodynamic

NCT03989817 ↗

Research trialsNCT01471990

Comparison between PACAP38 and VIP induced changes in intracranial artery circumference before and after infusions

NCT01471990 ↗

Research trialsNCT00272896

Headache

NCT00272896 ↗

Research trialsNCT00464932

Completed; results not posted

NCT00464932 ↗

Clinician practicePeptide List

Dose 200 mcgFrequency dailyRoute subQ

Peptide List — Longevity Insights LLC (peptidelist.org) ↗

Clinician practiceInternational Peptide Society monograph

IPS monograph exists but is members-only; awaiting authenticated session cookie.

International Peptide Society monograph (members-only) ↗

Peptide Deep Dive

Peptide Deep Dive is not projected for this peptide yet.

Regulatory safety notes

Warnings and precautions

• WARNINGS: Consult a physician for use in children under 12 years of age. IF PREGNANT OR BREASTFEEDING, ask a health care professional before use. In case of overdose (or accidental ingestion) get medical help or contact a Poison Control Center right away. KEE…

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