NSI-189
NSI-189 is an experimental aminopyridine-benzylpiperazine developed by Neuralstem for hippocampal neurogenesis and major depressive disorder; off-label, people run it mainly for depression and mood improvement, with a smaller cluster using it for cognition, across a total of seven captured community reports. Community protocols are inconsistent on exact milligrams, but the dominant pattern is a once-daily morning administration taken continuously without cycling. The honest tradeoff is that the off-label evidence base is thinner than surrounding discussion suggests; exploratory human trials for depression exist, yet most have not posted results.
Research Evidence
Evidence shape
NSI-189 carries a low evidence tier; the strongest mapped human work is a thin, exploratory program in depression and major depressive disorder, spanning four registered trials with two completed and only one linked publication, while the third mapped indication remains animal-only mechanistic research. The defining signal is absence: no later-stage program exists, and the gap between trial registration and published results is the most reliable feature of the dataset.
Anecdotal efficacy
Side effects
Clinical research side effects
Clinical safety table not projected yet.
Anecdotal side effects
Price
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Dosing & Protocol
How NSI-189 is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.
- Frequency
- daily
- Timing
- unspecified
- Route
- oral
- Cycle
- unspecified
2 completed trials identified; trial dosing not reliably extracted from registry data.
No structured protocol details captured for this tier yet.
- Frequency
- unspecified
- Timing
- unspecified
- Route
- oral
- Cycle
- unspecified
Anecdotal reports suggest that users typically take NSI-189 orally, with doses generally ranging from 10 mg to 40 mg once daily. Doses are often based on personal experimentation rather than structured protocols.
Peptide Deep Dive
Peptide Deep Dive is not projected for this peptide yet.
Peptide feedback
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