MOTS-c
MOTS-c is a mitochondria-derived peptide that regulates metabolic homeostasis; the bulk of off-label use targets exercise performance and obesity management, while a smaller segment reports it for metabolic health and insulin sensitivity. Community reports and clinician references converge on 5 mg injected subcutaneously each morning, with most sources recommending the peptide be cycled for four to six weeks. The central tradeoff is that the off-label evidence base is thinner than online discussion implies, with exploratory indications mostly lacking posted results.
Research Evidence
Evidence shape
Evidence for MOTS-c is low, resting on one thin, exploratory prediabetes trial that remains recruiting and a separate animal-only track of preclinical research. No trials have completed or posted results, so the entire human dataset is a single active study with no finished outcomes to evaluate. That leaves prediabetes studied but not at scale, with every other indication confined to animal models and no human data beyond that one active trial.
Anecdotal efficacy
Side effects
Clinical research side effects
Clinical safety table not projected yet.
Anecdotal side effects
Price
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Dosing & Protocol
How MOTS-c is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.
- Timing
- unspecified
- Cycle
- unspecified
1 completed trial identified; trial dosing not reliably extracted from registry data.
- Frequency
- daily
- Timing
- unspecified
- Route
- subQ
- Cycle
- unspecified
Clinician protocols dose 5 mg daily subQ (3 sources).
No structured protocol details captured for this tier yet.
Among anecdotal reports, MOTS-c use is discussed for exercise performance and obesity management, with positive reports in 88.9% of 27 cases. For metabolic health and insulin sensitivity, 64.7% of 17 reports were positive. Specific dosing from community posts is not consistently available.
Peptide Deep Dive
Peptide Deep Dive is not projected for this peptide yet.
Peptide feedback
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