Kisspeptin-10

Kisspeptin-10 is a KISS1 decapeptide fragment that activates GPR54 to regulate the hypothalamic-pituitary-gonadal axis; off-label, users run it for hormone regulation and libido, with six captured reports showing an around 83% positive response rate. Clinician protocols land on 100–200 mcg daily via subcutaneous injection, timed in the morning and cycled two to four weeks, while community dosing remains undefined and taken as-needed. The central caveat is that the off-label evidence base is thinner than the discourse suggests; most exploratory indications have no posted results.

Kisspeptin-10

Research Evidence

Evidence shape

Kisspeptin-10 holds moderate evidence; the strongest human data is a single Phase 2 infertility trial that reported a +13.0 percentage change in expected oocyte yield. Only two blinded trials have posted results, three distinct sponsors have registered trials, and pooled adverse-event data from two trials show a 19% withdrawal rate. Most of the ten mapped indications remain thin—six are exploratory, one is animal-only, five are single-trial long-tails—and most of the ten completed trials have yet to post results.

Depthhow much
16 registered trials
10 completed · 3 with posted results · 3 recruiting / active · combined n=227
Breadthhow many areas
10 indications mapped
1 with results · 6 thin / exploratory · 1 animal-only · 5 single-trial long-tail
Qualityhow rigorous
Highest tier: Phase 2
2 blinded with results · 3 distinct sponsors · 19% withdrawal rate · AE rows aggregated from 2 trials · 12 linked publications on registered trials
Breadth and depth40 rows captured
Human
direct clinical signal
16
Animal
translational support
12
In vitro
mechanistic support
12
HighMediumLow

Anecdotal efficacy

Side effects

Clinical research side effects

Anecdotal side effects

Price

1
High Purity Peptides
HK
100 mg
$90.00
$0.9/mg
2
Edge Peptides
CN
100 mg
$250.00
$2.5/mg
3
Union Biolabs
UK
10 mg
$29.64
$2.96/mg
4
Puratek Peptides
--
10 mg
$31.45
$3.15/mg
5
Panda Peptides
Fair Oaks, CA, USA
10 mg
$33.99
$3.4/mg
6
Nextgen Peptides
US
10 mg
$35.00
$3.5/mg

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Dosing & Protocol

How Kisspeptin-10 is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.

Research trials
Published clinical-trial protocols · n = 10
Typical dose
No quantified dose captured for this tier.
Timing
unspecified
Cycle
unspecified

10 completed trials identified; trial dosing not reliably extracted from registry data.

8 sources
Clinician practice
Doctor & published-protocol guidance · n = 3
Typical dose
100 µg50 µg – 200 µg
50 µg
100 µg
125 µg
Frequency
BID
Timing
unspecified
Route
subQ
Cycle
unspecified

Clinician protocols dose 50 µg–200 µg BID subQ (3 sources).

3 sources
Anecdotal
Community-reported real-world use · n = 6
Typical dose
No quantified dose captured for this tier.

No structured protocol details captured for this tier yet.

Anecdotal reports primarily discuss Kisspeptin-10 for hormone regulation and libido enhancement, with 6 reports showing 83.3% positive efficacy. Dosing specifics are not consistently reported within these anecdotal accounts.

Peptide Deep Dive

Peptide Deep Dive is not projected for this peptide yet.

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