FOXO4-DRI
FOXO4-DRI is a D-retro-inverso senolytic peptide that disrupts the FOXO4-p53 interaction to selectively clear senescent cells; people run it off-label for senolysis and general longevity, though the human record is thin—seven captured community reports, most focused on cell clearance with mostly positive reports, over an animal-only preclinical base. The only available clinician-level source recommends 5 mg injected subcutaneously daily, while community logs rarely specify dose. It carries no FDA-approved indication, so all human use is strictly off-label and compounded.
Research Evidence
Evidence shape
The evidence for FOXO4-DRI is animal-only, drawn entirely from preclinical and mechanistic animal studies with no human trials in the record. Only one indication is mapped, and the ledger shows zero registered trials and no completed studies of any kind to evaluate. That total absence—no posted results, no terminated or withdrawn programs, no human safety or efficacy data to inspect—is the signal that this peptide has never been tested in people.
Anecdotal efficacy
Side effects
Clinical research side effects
Clinical safety table not projected yet.
Anecdotal side effects
Price
price offers can be sorted by column
Dosing & Protocol
How FOXO4-DRI is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.
No structured protocol details captured for this tier yet.
- Frequency
- daily
- Timing
- unspecified
- Route
- subQ
- Cycle
- unspecified
Clinician protocols dose 5 mg–10 mg daily subQ (3 sources).
- Frequency
- unspecified
- Timing
- unspecified
- Route
- SubQ
- Cycle
- unspecified
Community reports suggest use of FOXO4-DRI for senescent cell clearance and general anti-aging purposes, with doses between 5-10 mg daily. Efficacy for senescent cell clearance was positive in the majority of 7 reports, and for anti-aging was positive in 2 reports.
Peptide Deep Dive
Peptide Deep Dive is not projected for this peptide yet.
Peptide feedback
0 forum repliesLive community discussion for FOXO4-DRI, shown here in the site layout and continued on the TVR forum.
No peptide feedback yet
Start the peptide feedback thread on the TVR forum.