Epithalon

Epithalon is a synthetic tetrapeptide derived from the pineal gland that users run primarily for sleep and circadian rhythm support, with a smaller group using it for anti-aging and longevity. In practice, community anecdotes rarely specify exact doses or schedules, so most guidance comes from clinician sources, which suggest a wide daily range of roughly 1–10 mg taken in the morning, usually by subcutaneous injection and run continuously. It carries no FDA-approved indication, so all human use is off-label or compounded.

Epithalon

Research Evidence

Evidence shape

Epithalon sits at the animal-only tier, supported entirely by preclinical mechanistic research and completely absent from human trial registries, with zero registered studies and zero completions. Only one indication is mapped across the entire database, and the quality line reads empty because no human trial has ever reported data. The signal of absence is total: no active, terminated, or withdrawn studies appear in the data, so the entire investigational footprint remains purely preclinical.

Depthhow much
0 registered trials
Breadthhow many areas
1 indication mapped
1 animal-only
Qualityhow rigorous
No completed trials
Breadth and depth24 rows captured
Human
direct clinical signal
0
Animal
translational support
12
In vitro
mechanistic support
12
HighMediumLow

Anecdotal efficacy

Side effects

Clinical research side effects

Clinical safety table not projected yet.

Anecdotal side effects

Price

1
Natty Peptides
UK
2400 mg
$40.03
$0.013/mg
2
Nextgenpeps
US
10 mg
$0.42
$0.042/mg
3
High Purity Peptides
HK
500 mg
$130.00
$0.26/mg
4
OP Labs
UK
10 mg
$7.95
$0.795/mg
5
Blueridgepeptides
US
70 mg
$65.00
$0.929/mg
6
Edge Peptides
CN
500 mg
$490.00
$0.98/mg

price offers can be sorted by column

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Dosing & Protocol

How Epithalon is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.

Research trials
Published clinical-trial protocols
Typical dose
No quantified dose captured for this tier.

No structured protocol details captured for this tier yet.

Clinician practice
Doctor & published-protocol guidance · n = 3
Typical dose
5 mg1 mg – 10 mg
1 mg
2 mg
3 mg
5 mg
10 mg
Frequency
daily
Timing
unspecified
Route
subQ
Cycle
unspecified

Clinician protocols dose 1 mg–10 mg daily subQ (3 sources).

3 sources
Anecdotal
Community-reported real-world use · n = 32
Typical dose
No quantified dose captured for this tier.
Frequency
unspecified
Route
subQ

Reddit users report Epithalon use for anti-aging and longevity, with 100% positive sentiment across 3 reports. For sleep and circadian rhythm, 69% of 29 reports were positive, 10.3% mixed, and 20.7% negative. Specific dosing details are not consistently reported in community discussions, but general ranges from clinician sources are often referenced.

Peptide Deep Dive

Peptide Deep Dive is not projected for this peptide yet.

Peptide feedback

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