Argireline

Argireline is a synthetic hexapeptide used topically in cosmetics to reduce expression wrinkles by inhibiting the neurotransmitter release that drives facial muscle contraction — a botox-like effect without injection. There is no FDA-approved indication; all human use is off-label or compounded. The registered clinical trial program has a 50% withdrawal rate, and the human evidence base is thin: one small wrinkle trial with results posted and one trial with no data at all.

Argireline

Research Evidence

Evidence shape

Argireline has two registered trials on record, one completed — a Phase 3 study in wrinkles that carried a 50% withdrawal rate. The remaining mapped indications offer less: preclinical and mechanistic work with no registered trials behind it, and focal dystonia with no trial data at all. The evidence base amounts to one compromised study and empty space everywhere else.

Depthhow much
2 registered trials
1 completed
Breadthhow many areas
3 indications mapped
2 thin / exploratory · 2 single-trial long-tail
Qualityhow rigorous
Highest tier: Phase 3
50% withdrawal rate
Breadth and depth6 rows captured
Human
direct clinical signal
2
Animal
translational support
0
In vitro
mechanistic support
4
HighMediumLow

Anecdotal efficacy

Side effects

Clinical research side effects

Clinical safety table not projected yet.

Anecdotal side effects

Price

1
BehemothLabz
US
200 mg
$214.96
$1.07/mg
2
Biotech Peptides
US
200 mg
$226.00
$1.13/mg
3
Core Peptides
US
200 mg
$226.00
$1.13/mg
4
OP Labs
UK
10 mg
$67.36
$6.74/mg
5
Evolvepeptides
US
5 mg
$119.90
$23.98/mg

price offers can be sorted by column

Dosing & Protocol

How Argireline is dosed across research, clinician, and community sources — each evidence tier kept separate so the dose range, frequency, timing, and cycling stay visible without flattening different levels of evidence.

Research trials
Published clinical-trial protocols · n = 1
Typical dose
No quantified dose captured for this tier.
Frequency
unknown
Timing
unspecified
Route
topical
Cycle
unspecified

1 completed trial identified; trial dosing not reliably extracted from registry data.

1 source
Clinician practice
Doctor & published-protocol guidance
Typical dose
No quantified dose captured for this tier.

No structured protocol details captured for this tier yet.

Anecdotal
Community-reported real-world use
Typical dose
No quantified dose captured for this tier.

No structured protocol details captured for this tier yet.

Peptide Deep Dive

Peptide Deep Dive is not projected for this peptide yet.

Regulatory safety notes

Warnings and precautions
  • • Warnings: For external use only. Avoid contact with eyes. Discontinue use if irritation occurs. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

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